Drug name  Artificial Cow-Bezoar,Metronidazole Capsules
Common name  Artificial Cow-Bezoar,Metronidazole Capsules
Trade name / brand Shaanxi
Main components This product is a compound preparation, which contains 200 mg metronidazole per capsule; Artificial bezoar 5mg.
character This product is a capsule with yellow or yellowish particles or powder.
Efficacy and function For acute wisdom tooth pericoronitis, local alveolar abscess, pulpitis, periapical periodontitis, etc.
Usage and dosage Oral. 2 capsules at a time, 3 times a day.
side effect 1. The most serious adverse reaction of this product is that high dose can cause epilepsy and peripheral neuropathy, which is mainly characterized by limb numbness and paresthesia. Persistent peripheral neuropathy can occur in some cases when long-term medication is used. 2. Other common adverse reactions include: (1) gastrointestinal reactions, such as nausea, anorexia, vomiting, diarrhea, abdominal discomfort, taste change, dry mouth, oral metal taste, etc. (2) Reversible granulocytopenia. (3) Allergic reaction, rash, urticaria, pruritus, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and insanity. (5) Others include fever, vaginal Rosary infection, cystitis, dysuria, dark urine color, etc., which are reversible and recover after drug withdrawal.
taboo 1. It is forbidden for patients allergic to metronidazole or pyrrole drugs. 2. It is forbidden for patients with active central nervous system diseases and hematological diseases. 3. Pregnant women are forbidden. 4. Drinkers are forbidden.
matters needing attention 1. Carcinogenic and mutagenic effects: it is found that this product has carcinogenic and mutagenic effects in animal test or in vitro determination. But it has not been confirmed in humans. 2. If any adverse reaction of central nervous system is found during use, the drug should be stopped in time. 3. This product can interfere with the test results of alanine transferase, lactate dehydrogenase, triacylglycerol, hexokinase, etc., and reduce the measured value to zero. 4. Do not drink alcoholic beverages during medication, because it can cause acetaldehyde accumulation in the body, interfere with the oxidation process of alcohol, and lead to disulfiram like reaction. Patients may have abdominal spasm, nausea, vomiting, headache, facial flushing, etc. 5. In patients with liver dysfunction, the metabolism of this product slows down, and the drug and its substitutes are easy to accumulate in the body, so it should be used less. Blood drug concentration was monitored. 6. This product can be continuously removed from gastric juice. Some people who place gastric tubes for suction and decompression can cause the decrease of blood drug concentration. During hemodialysis, this product and metabolites are quickly removed, so this product does not need to be reduced. 7. If this product is used in patients with Candida infection, their symptoms will worsen. Antifungal therapy should be given at the same time. 8. For patients with anaerobic infection complicated with renal failure, the interval of administration should be extended from 8 hours to 12 hours. 9. When treating vaginal trichomoniasis, it is necessary to treat its sexual partner at the same time. 10. White blood cells should be counted before repeating a course of treatment.
Interaction 1. Metronidazole can inhibit the metabolism of warfarin and other oral anticoagulants, strengthen their effects and prolong prothrombin time. 2. Combined with phenytoin sodium, phenobarbital and other drugs that induce liver microsomal enzymes, it can strengthen the metabolism of this product, reduce the blood drug concentration, and slow down the excretion of phenytoin sodium. 3. Combined with cimetidine and other drugs that inhibit the activity of liver microsomal enzymes, it can slow down the metabolism and excretion of the product in the liver and prolong the blood elimination half-life (T1 / 2) β）， The dosage should be adjusted according to the results of blood drug concentration measurement. 4. This product can interfere with disulfiram metabolism. When combined, patients can have mental symptoms after drinking, so it should not be used again for disulfiram application within 2 weeks. 5. This product can interfere with the results of serum aminotransferase and lactate dehydrogenase, and reduce the levels of cholesterol and triacylglycerol.
Storage Shading and sealing, and place in a dry place.
term of validity 24 months
Approval number Gyzz h61022799